Many cats panic or even vomit during car rides. My younger cat, Millie does not like to be in her cage in the car unless the cage is in the passenger seat next to the driver.  There are some ways to prevent your cat from getting sick.  Try getting her used to the carrier at home where she could sleep and play in it. When you do go for a ride, cover the carrier with a blanket, so your cat feels safe.  Try taking her for some short trial runs before taking her for a long drive.  To prevent vomiting, it’s a good idea to keep your cats stomach empty on the day of travel. Feed her when you get to your destination instead of before you go. These simple steps will help your cat become a better traveler. If everything that you’ve tried, just doesn’t work, ask your vet to get her some pet medication such as tranquilizers to help calm her during the drive.