Depending on how much pain your cat is feeling, a cat with a splinter may be quiet or very hard to deal with. One way or another, the splinter needs to come out.  If your cat is OK with you handling her paw, get some tweezers and gently remove the splinter.  Rub in some alcohol, or pet medication such as antibiotic salve and you’re done.  If your cat’s in pain and is frantic, you’re probably going to need help. Ask a friend or neighbor to hold the cat while you gently place a towel over her body and wrap it around her. Leave her head and the paw with the splinter exposed. If you use this strategy, you can work slowly and carefully to get the splinter out.  If the situation is more difficult for you to handle on your own, turn to your veterinarian.